Alternatives to knee replacement… fibroblast growth factor as an aid to stem cell cartilage repair

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Alternatives to knee replacement… fibroblast growth factor as an aid to stem cell cartilage repair



In our series on alternatives to knee replacement, let’s go over some of the growth factors needed for cartilage growth and maintenance… let’s talk about Fibroblast growth factor
Fibroblast growth factors (FGF) are proteins that play a major role in the development of normal cartilage and bone. Genetic mutations that cause deficiencies of this protein result in significant skeletal abnormalities. In rat studies, FGF has demonstrated impressive abilities to stimulate cartilage repair in osteoarthritis. On the other hand FGF, under certain circumstances has been shown to inhibit the effects of other growth factors such as Insulin-like growth factor. Its use as an adjunctive ingredient in the application of mesenchymal stem cells for cartilage repair bears watching.
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