Can gene transfer be used to repair cartilage?

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Can gene transfer be used to repair cartilage?



In a unique twist to the stem cell cartilage repair and arthritis treatment issue comes another innovative approach. Gene transfer to heal joint damage in rheumatoid arthritis was first described by Evans. Perhaps the same technology can be applied to osteoarthritis. For the purpose of cartilage repair, complementary DNAs include members of the transforming growth factor family, bone morphogenetic proteins, insulin-like growth factor, fibroblast growth factors , and epidermal growth factor (EGF)- all of which can be delivered via genes.
Alternatively, to support production and maintenance of hyaline cartilage matrix, delivery, and expression of complementary DNAs encoding components such as collagen type II, tenascin, or cartilage matrix protein may also be used, as described by Dharmavaram.
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