Cartilage repair… a real problem!

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Cartilage repair… a real problem!



Hyaline articular cartilage is a highly specialized tissue. Buckwalter and Hunziger have both commented that the function of cartilage is to protect the bones of joints from friction, forces associated with load bearing and impact. The problem with this tissue is its durability. Once articular cartilage is injured or degenerated, it has very limited capacities for self-repair and regeneration. In partial thickness lesions, there is no involvement of blood vessels. Consequently, cells from marrow or blood cannot reach the damaged region to heal the tissue. The consequence of cartilage nonvascularity is that cartilage cells are not able to migrate towards the lesion and fill the defect. As such, the defect is not repaired and remains permanent.
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