Don’t breathe… you’ll kill the cartilage!

1 Star2 Stars3 Stars4 Stars5 Stars (No Ratings Yet)
Loading ... Loading ...

Don’t breathe… you’ll kill the cartilage!



Punwar and Khan described the role of oxygen in cartilage repair. Because cartilage is a primarily avascular tissue a relatively hypoxic environment is created. It has been postulated that this hypoxia is important for cartilage growth and efforts have attempted to mimic this environment. Hypoxic conditions have been shown to enhance the ability to produce collagen type II and glycosaminoglycans. They showed that bone marrow derived MSCs undergoing cartilage differentiation exhibit enhanced growth under hypoxic conditions (5% oxygen) as compared to normoxic culture conditions (20% oxygen).

Author’s Google+

Comments are closed.