Growth factors for cartilage repair- TGF beta

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Growth factors for cartilage repair- TGF beta



The first growth factor is transforming growth factor beta, TGF beta for short. It is a critical ingredient in the genesis of both cartilage as well as of bone. TGF beta is a potent stimulator of proteoglycan and collagen synthesis, the key compounds found in cartilage. Multiple experiments in animal models have confirmed that TGF-beta is instrumental in the differentiation of mesenchymal stem cells into cartilage and helps integrate the newly formed cartilage into bone underlying the cartilage. This is key to the development of cartilage as well as to the cartilage laying down on bone… all important elements for cartilage repair and healing when stem cells are used.
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