How can cartilage heal if cartilage doesn’t grow?

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How can cartilage heal if cartilage doesn’t grow?



In most of the studies looking at the therapeutic efficacy of mesenchymal stem cells in regenerating cartilage did not correlate with the efficiency of graft growth, which was usually poor. These findings suggest that the ability to repair was very likely due to both the differentiation of the cells into the appropriate type, but also by the secretion of factors that altered the joint environment. In other words stem cells may have a healing effect on injured tissues. Caplan and Dennis showed that mesenchymal stem cells produce a number of factors that influence a broad range of biological functions, including blood vessel growth, and also secrete peptides and cytokines with critical roles in inflammation and repair.
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