How do stem cells form cartilage?

1 Star2 Stars3 Stars4 Stars5 Stars (No Ratings Yet)
Loading ... Loading ...

How do stem cells form cartilage?



Hyaline cartilage- the tough cartilage that caps the ends of long bones- is formed of several different cell layers. The uppermost layer is formed by articular chondrocytes progressing to hypertrophic chondrocytes and underlying subchondral bone. Caplan, in a rabbit model, observed that mesenchymal stem cells transplanted into full thickness cartilage defects could recreate this layered arrangement. Initially the cells rapidly differentiated into embryonic cartilage. Chondrocytes at the defect base then differentiate into hypertrophic chondrocytes which are subsequently replaced by blood vessels and early bone cells leading to the production of new subchondral bone. The top cartilage remained as articular cartilage probably from exposure to factors circulating inside the joint.

Author’s Google+

Comments are closed.