More studies showing stem cell efficacy in cartilage repair

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More studies showing stem cell efficacy in cartilage repair



A one-step repair technique with bone-marrow-derived cells was developed by Gianinni et al. They reported good clinical results in both the ankle and knee. As well as bone marrow aspiration, the technique involved creating a platelet-rich fibrin gel from a sample of the patient’s blood. The bone marrow was concentrated by centrifugation and implanted onto a hyaluronic acid membrane which was then placed into the cartilage defect and covered with the platelet-rich gel. Wakitani et al. reported using undifferentiated bone marrow derived MSC associated with a collagen sheet to repair chondral defects. Haleem et al. used MSCs transplanted on a scaffold of platelet-rich fibrin glue in the treatment of articular cartilage. Platelet-rich fibrin glue may be an ideal MSC scaffold as the α-secretory granules of platelets contain both TGF-β1 and IGF-1

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