Natural scaffolds for stem cells… critical step or overhyped?

1 Star2 Stars3 Stars4 Stars5 Stars (1 votes, average: 5.00 out of 5)
Loading ... Loading ...

Natural scaffolds for stem cells… critical step or overhyped?



There are a number of natural biomaterials that have been used in experiments in tissue engineering. Protein-based compounds include collagen, fibrin, fibrinogen, and silk. Collagen seems to be the most popular of these. I can be transformed into a 3 dimensional matrix. Stem cells are attracted to the scaffold and form blood vessels inside it. Multiple studies have demonstrated that the use of these 3-D collagen scaffolds along with stem cell seeding may have utility in the construction of ligaments, cartilage, and bone. Fibrin, while not studied as much as collagen, also appears to have promise. Silk, used as a 3-D scaffold also has promise. Meinel and colleagues demonstrated that human mesenchymal stem cells combined with silk scaffolds produced more cartilage than comparable collagen 3D scaffolds. Silk has tensile strength that makes it attractive for engineering connective tissue.
Author’s Google+

Comments are closed.