New targets for disease modifying osteoarthritis drugs… promise for osteoarthritis treatment?

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New targets for disease modifying osteoarthritis drugs… promise for osteoarthritis treatment?



Blanco and Ruiz-Romero writing in the Annals of the Rheumatic Diseases reported that because cells with chondrogenic capacity have been identified in healthy and diseased articular tissues (cartilage and synovium) and appear to retain at least some potential to regenerate/repair cartilage in vivo, compounds with chondrogenic capacity are a good option for development of a new DMOAD. Transcription factor Runx1 appears to be an ideal target to stimulate chondrogenesis in the joint. Drugs with the capacity to modulate Runx1 activity, when administered directly into the joint space, successfully stopped the degeneration of articular cartilage in a surgically-induced OA mouse model. What would be interesting would be to combine a compound like this along with stem cells.
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