Rejection… a problem with stem cells for arthritis treatment… or not?

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Rejection… a problem with stem cells for arthritis treatment… or not?



Stem cells may not be rejected… here’s why…
Ryan and colleagues in an article from the National University of Ireland and published in the Journal of Inflammation. Mesenchymal stem cells avoid rejection in humans and in animal models. These finding are supported by in vitro studies. Three broad mechanisms contribute to this effect. Firstly, mesenchymal stem cells are hypoimmunogenic. Secondly, these stem cells prevent T cell responses. Thirdly, mesenchymal stem cells induce a suppressive local microenvironment through the production of prostaglandins and interleukin-10. Comparison is made to maternal tolerance of the fetal allograft, and contrasted with the immune evasion mechanisms of tumor cells. Mesenchymal stem cells are a highly regulated self-renewing population of cells with potent mechanisms to avoid allogeneic rejection.
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