Stem cell cartilage repair: Lessons learned from a goat model

1 Star2 Stars3 Stars4 Stars5 Stars (No Ratings Yet)
Loading ... Loading ...

Stem cell cartilage repair: Lessons learned from a goat model



A study by Murphy and colleagues using mesenchymal stem cells in a goat model of osteoarthritis of the knee highlighted the regenerative effect of MSC cell therapy in osteoarthritis- OA. Trauma-induced OA was simulated by cutting out the medial meniscus and also cutting the anterior cruciate ligament, followed by exercise. Autologous mesenchymal stem cells in hyaluronan solution were injected into the joint. In the control animals without mesenchymal stem cells, OA development was observed as expected. In the mesenchymal stem cell treated joints, there was marked regeneration of the medial meniscus and decreased cartilage destruction and bone changes. Injected labeled MSCs were not seen engrafted on articular cartilage. Labeled MSCs were seen engrafted in the early meniscus tissue though not in a large enough quantity to account for the majority of the newly formed tissue. These findings suggested that the beneficial effect of MSCs on cartilage protection and on OA progression was not due to the direct structural contribution of MSCs. It is possible that the injected MSCs acted to induce the goat’s progenitor cells to regenerate meniscus, which in turn slowed cartilage degeneration associated with OA.
Author’s Google+

Comments are closed.