Stem cells suppress inflammation… Hallelujah!

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Stem cells suppress inflammation… Hallelujah!

Desando and colleagues reported, in a study published in Arthritis Research and Therapy, that the healing capacity of fat-derived stem cells in osteoarthritis may be due to a two fold effect.

Not only can stem cells be used to differentiate into cartilage cells. They may also promote cartilage and meniscus repair by suppressing inflammatory events in the joint inhibiting OA progression. This is key to the use of stem cells for arthritis treatment and cartilage repair.

Adipose-derived stem cells) have been shown to exhibit immune suppressive properties and release anti-inflammatory molecules like IL-10, IL-1 receptor antagonist (IL-1ra, transforming growth factor (TGF)β, and prostaglandin E2 The benefits obtained by stem cell treatment could be due to a mechanism of action incorporating both the release of growth factors as well as anti-inflammatory cytokines.
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