What are the Risk Factors for Developing Osteoarthritis

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What are the Risk Factors for Developing Osteoarthritis







Today’s episode is about risk factors for osteoarthritis… what are they?
There are three major risk factors for the development of osteoarthritis. They are genetic (usually a family history is prominent), constitutional (obesity in the case of OA of the knee, and aging), and finally local components (injury, ligamentous laxity, congenital abnormalities).
The development of osteoarthritis starts with an initial injury to cartilage. Cartilage consists of cells called chondrocytes that sit inside a “soup”, a matrix, which consists of collagen and proteoglycans.
The injury may trigger an inflammatory response leading to the synthesis of degrading enzymes, produced by chondrocytes. These cause cartilage damage.

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