What is the target for stem cells placed into an arthritic joint?

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What is the target for stem cells placed into an arthritic joint?



An article by van Lent and van den Berg from Radboud University Medical Centre, Nijmegen, The Netherlands provided some interesting information. In osteoarthritis, release of cartilage fragments from damaged cartilage may stimulate synovial macrophages, inflammatory cells that drive inflammation of the lining of the joint. Recent studies performed in animal osteoarthritis models show that a single local administration of fat-derived stem cells into OA joints causes suppression of synovial activation, and improves damage to the ligaments and menisci which occur with osteoarthritis. This suppression of inflammation of the lining of the joint may inhibit cartilage destruction and new formation of cartilage/bone that causes the spur formation seen with osteoarthritis.
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